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Generic Name: sodium hyaluronate (injection) (SO dee um HYE al yoo RON ate)
Brand Name:Durolane, Euflexxa, Gel-One, Gelsyn-3, Hyalgan, Supartz

Medically reviewed by Drugs.com on Mar 17, 2020 – Written by Cerner Multum

What is Gel-One?

Gel-One is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints.

Gel-One is used to treat knee pain caused by osteoarthritis.

Gel-One is usually given when other arthritis medications have not been effective.

Gel-One may also be used for purposes not listed in this medication guide.

Important Information

You should not receive a Gel-One if you have an infection in your knee or in the skin around your knee.

Before taking this medicine

You should not receive Gel-One if you are allergic to it, or if you have an infection in your knee or in the skin around your knee.

Gel-One is not approved for use by anyone younger than 21 years old.

Tell your doctor if you have ever had:

blood clots or circulation problems in your legs; or
an allergy to birds, feathers, or egg products.

It is not known whether Gel-One will harm an unborn baby. Tell your doctor if you are pregnant.

It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.

How is Gel-One given?

Gel-One is injected directly into your knee joint. A healthcare provider will give you this injection.

Gel-One is usually given once every week for 3 to 5 weeks. Follow your doctor's dosing instructions very carefully.

To prevent pain and swelling, your doctor may recommend resting your knee or applying ice for a short time after your injection.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Tell your doctor if your symptoms do not improve, or if they get worse.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Gel-One.

What happens if I overdose?

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

What should I avoid after receiving Gel-One?

For at least 48 hours after your injection, avoid jogging, strenuous activity, or high-impact sports such as soccer or tennis. Also avoid weight-bearing activity or standing for longer than 1 hour at a time. Ask your doctor how long to wait before you resume these activities.

Gel-One side effects

Get emergency medical help if you have signs of an allergic reaction:hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

severe pain or swelling around the knee after the injection.

Common side effects may include:

warmth, pain, redness, stiffness, bruising, or puffiness where the medicine was injected;
nausea, stomach pain;
trouble walking;
swelling in your hands or feet;
back pain, joint pain, muscle pain;
numbness or tingly feeling;
headache, dizziness; or
runny or stuffy nose, sneezing, sore throat.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Gel-One?

Other drugs may affect Gel-One, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.